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Celebrex is used to reduce pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Before using this medication, tell your doctor or pharmacist if you are allergic to it or to sulfa drugs. This medicine. Fluconazole increases the concentration of Celecoxib in the liver. Celecoxib is used to reduce pain and inflammation in osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It reduces only the symptoms and signs of arthritis. Celecoxib should only be used in pregnant women when the benefits outweigh the potential risk to the fetus. This medicine.